S75F (p.Ser75Phe) variant of KRT3 (Keratin, type II cytoskeletal 3)
S75F (p.Ser75Phe) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
S75F (p.Ser75Phe) variant details
- p.Ser75Phe
- rs761759347
- NCI-TCGA Cosmic COSV1005
- 1000Genomes rs761759347
- ExAC rs761759347
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.32
- REVEL 0.30
- CADD 15.80
- PolyPhen-2 0.81
- SIFT 0.74
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available