S35Y (p.Ser35Tyr) variant of KRT3 (Keratin, type II cytoskeletal 3)
S35Y (p.Ser35Tyr) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
S35Y (p.Ser35Tyr) variant details
- p.Ser35Tyr
- rs1389289222
- NCI-TCGA Cosmic COSV1005
- NCI-TCGA Cosmic COSV5881
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.372
- REVEL 0.39
- CADD 12.00
- PolyPhen-2 0.33
- SIFT 0.11
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available