S17F (p.Ser17Phe) variant of KRT3 (Keratin, type II cytoskeletal 3)
S17F (p.Ser17Phe) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
S17F (p.Ser17Phe) variant details
- p.Ser17Phe
- NCI-TCGA Cosmic COSV5881
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.529
- REVEL 0.58
- CADD 20.70
- PolyPhen-2 0.16
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:MAKRANI population (allele frequency 0.023)
- Structural context available