M115I (p.Met115Ile) variant of KRT3 (Keratin, type II cytoskeletal 3)
M115I (p.Met115Ile) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
M115I (p.Met115Ile) variant details
- p.Met115Ile
- ExAC rs747082128
- TOPMed rs747082128
- gnomAD rs747082128
- Missense
- Variant Prioritization Score for Impact Estimate 0.143
- REVEL 0.18
- CADD 3.33
- PolyPhen-2 0.00
- SIFT 0.43
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available