G92C (p.Gly92Cys) variant of KRT3 (Keratin, type II cytoskeletal 3)
G92C (p.Gly92Cys) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
G92C (p.Gly92Cys) variant details
- p.Gly92Cys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.34
- REVEL 0.45
- CADD 17.30
- PolyPhen-2 0.67
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available