G25S (p.Gly25Ser) variant of KRT3 (Keratin, type II cytoskeletal 3)
G25S (p.Gly25Ser) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
G25S (p.Gly25Ser) variant details
- p.Gly25Ser
- rs750421344
- NCI-TCGA Cosmic COSV5881
- ExAC rs750421344
- TOPMed rs750421344
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.229
- REVEL 0.22
- CADD 6.72
- PolyPhen-2 0.25
- SIFT 0.25
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available