G25D (p.Gly25Asp) variant of KRT3 (Keratin, type II cytoskeletal 3)
G25D (p.Gly25Asp) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
G25D (p.Gly25Asp) variant details
- p.Gly25Asp
- rs1466295880
- NCI-TCGA Cosmic COSV1005
- TOPMed rs1466295880
- gnomAD rs1466295880
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.406
- REVEL 0.30
- CADD 22.00
- PolyPhen-2 0.89
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:MAKRANI population (allele frequency 0.023)
- Structural context available