C31Y (p.Cys31Tyr) variant of KRT3 (Keratin, type II cytoskeletal 3)
C31Y (p.Cys31Tyr) in KRT3 (Keratin, type II cytoskeletal 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
C31Y (p.Cys31Tyr) variant details
- p.Cys31Tyr
- rs777747344
- ExAC rs777747344
- TOPMed rs777747344
- gnomAD rs777747344
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.387
- AlphaMissense 0.14
- MetaLR 0.24
- MetaSVM -0.93
- PolyPhen-2 0.00
- SIFT 0.81
- MutPred 0.40
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available