G59S (p.Gly59Ser) variant of KRT2 (P35908)
G59S (p.Gly59Ser) in KRT2 (P35908) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
G59S (p.Gly59Ser) variant details
- p.Gly59Ser
- 1000Genomes rs553386913
- ExAC rs553386913
- TOPMed rs553386913
- gnomAD rs553386913
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.17
- CADD 10.70
- PolyPhen-2 0.01
- SIFT 0.23
- Most common in the Middle Eastern population (allele frequency 0.0007)
- Structural context available