G105S (p.Gly105Ser) variant of KRT2 (P35908)
G105S (p.Gly105Ser) in KRT2 (P35908) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
G105S (p.Gly105Ser) variant details
- p.Gly105Ser
- ExAC rs780972647
- gnomAD rs780972647
- Missense
- Variant Prioritization Score for Impact Estimate 0.321
- REVEL 0.37
- CADD 13.90
- PolyPhen-2 0.56
- SIFT 0.20
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available