R45P (p.Arg45Pro) variant of KRT18 (Keratin, type I cytoskeletal 18)
R45P (p.Arg45Pro) in KRT18 (Keratin, type I cytoskeletal 18) is a missense change. The available record places it in the context of Hepatitis C virus, susceptibility to. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
R45P (p.Arg45Pro) variant details
- p.Arg45Pro
- rs200221269
- ClinGen CA144197
- cosmic curated COSV66315
- ClinVar RCV000049578
- not provided
- Hepatitis C virus, susceptibility to
- Missense
- Variant Prioritization Score for Impact Estimate 0.501
- REVEL 0.52
- CADD 25.20
- PolyPhen-2 0.02
- SIFT 0.04
- ClinVar: not provided (Hepatitis C virus, susceptibility to)
- UniProt: Not provided
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available