S25P (p.Ser25Pro) variant of KRT17 (Keratin, type I cytoskeletal 17)
S25P (p.Ser25Pro) in KRT17 (Keratin, type I cytoskeletal 17) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
S25P (p.Ser25Pro) variant details
- p.Ser25Pro
- rs1443619298
- gnomAD rs1443619298
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.459
- REVEL 0.45
- CADD 25.20
- PolyPhen-2 0.89
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:MSL population (allele frequency 0.013)
- Structural context available