L35M (p.Leu35Met) variant of KRT14 (Keratin, type I cytoskeletal 14)
L35M (p.Leu35Met) in KRT14 (Keratin, type I cytoskeletal 14) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L35M (p.Leu35Met) variant details
- p.Leu35Met
- NCI-TCGA Cosmic COSV9939
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.259
- REVEL 0.13
- CADD 14.70
- PolyPhen-2 0.29
- SIFT 0.22
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available