G16D (p.Gly16Asp) variant of KRT14 (Keratin, type I cytoskeletal 14)
G16D (p.Gly16Asp) in KRT14 (Keratin, type I cytoskeletal 14) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
G16D (p.Gly16Asp) variant details
- p.Gly16Asp
- NCI-TCGA Cosmic COSV9939
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.594
- REVEL 0.49
- CADD 23.80
- PolyPhen-2 0.25
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.6e-05)
- Structural context available