F8S (p.Phe8Ser) variant of KRT14 (Keratin, type I cytoskeletal 14)
F8S (p.Phe8Ser) in KRT14 (Keratin, type I cytoskeletal 14) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
F8S (p.Phe8Ser) variant details
- p.Phe8Ser
- TOPMed rs1156635262
- gnomAD rs1156635262
- Missense
- Variant Prioritization Score for Impact Estimate 0.257
- REVEL 0.13
- CADD 22.40
- PolyPhen-2 0.00
- SIFT 0.10
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available