Y65H (p.Tyr65His) variant of KRT13 (Keratin, type I cytoskeletal 13)
Y65H (p.Tyr65His) in KRT13 (Keratin, type I cytoskeletal 13) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
Y65H (p.Tyr65His) variant details
- p.Tyr65His
- rs1001394879
- NCI-TCGA Cosmic COSV9987
- cosmic curated COSV99877
- TOPMed rs1001394879
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.131
- REVEL 0.10
- CADD 14.30
- PolyPhen-2 0.00
- SIFT 0.32
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:FRENCH population (allele frequency 0.019)
- Structural context available