Y65F (p.Tyr65Phe) variant of KRT13 (Keratin, type I cytoskeletal 13)
Y65F (p.Tyr65Phe) in KRT13 (Keratin, type I cytoskeletal 13) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
Y65F (p.Tyr65Phe) variant details
- p.Tyr65Phe
- NCI-TCGA Cosmic COSV9987
- cosmic curated COSV99877
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0784
- REVEL 0.08
- CADD 1.22
- PolyPhen-2 0.00
- SIFT 0.76
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available