D151Y (p.Asp151Tyr) variant of KRT13 (Keratin, type I cytoskeletal 13)
D151Y (p.Asp151Tyr) in KRT13 (Keratin, type I cytoskeletal 13) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
D151Y (p.Asp151Tyr) variant details
- p.Asp151Tyr
- rs1458787161
- NCI-TCGA Cosmic COSV5584
- NCI-TCGA Cosmic COSV9987
- cosmic curated COSV99877
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.628
- REVEL 0.60
- CADD 24.60
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available