G91E (p.Gly91Glu) variant of KRT12 (Keratin, type I cytoskeletal 12)
G91E (p.Gly91Glu) in KRT12 (Keratin, type I cytoskeletal 12) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
G91E (p.Gly91Glu) variant details
- p.Gly91Glu
- NCI-TCGA Cosmic COSV9928
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.23
- CADD 17.50
- PolyPhen-2 0.26
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available