S33T (p.Ser33Thr) variant of KRT10 (Keratin, type I cytoskeletal 10)
S33T (p.Ser33Thr) in KRT10 (Keratin, type I cytoskeletal 10) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data.
S33T (p.Ser33Thr) variant details
- p.Ser33Thr
- rs141187850
- ClinGen CA8548361
- ClinVar RCV003089251
- ESP rs141187850
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.247
- REVEL 0.21
- CADD 8.96
- PolyPhen-2 0.12
- SIFT 0.21
- ClinVar: Uncertain significance (not provided)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00091)