R86C (p.Arg86Cys) variant of KRT10 (Keratin, type I cytoskeletal 10)
R86C (p.Arg86Cys) in KRT10 (Keratin, type I cytoskeletal 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data.
R86C (p.Arg86Cys) variant details
- p.Arg86Cys
- rs1319705744
- NCI-TCGA Cosmic COSV5409
- gnomAD rs1319705744
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.28
- REVEL 0.17
- AlphaMissense 0.43
- MetaLR 0.27
- MetaSVM -0.47
- CADD 14.20
- PolyPhen-2 0.92
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:CLM population (allele frequency 0.0053)