G22E (p.Gly22Glu) variant of KRT10 (Keratin, type I cytoskeletal 10)
G22E (p.Gly22Glu) in KRT10 (Keratin, type I cytoskeletal 10) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data.
G22E (p.Gly22Glu) variant details
- p.Gly22Glu
- rs968911030
- NCI-TCGA Cosmic COSV9950
- TOPMed rs968911030
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.447
- REVEL 0.33
- CADD 20.70
- PolyPhen-2 0.70
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 0.00031)