G36R (p.Gly36Arg) variant of KIF5A (Kinesin heavy chain isoform 5A)
G36R (p.Gly36Arg) in KIF5A (Kinesin heavy chain isoform 5A) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
G36R (p.Gly36Arg) variant details
- p.Gly36Arg
- NCI-TCGA Cosmic COSV5405
- cosmic curated COSV54055
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.419
- REVEL 0.19
- CADD 23.90
- PolyPhen-2 0.11
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available