T2M (p.Thr2Met) variant of KCNA1 (Q09470)
T2M (p.Thr2Met) in KCNA1 (Q09470) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data and structural context.
T2M (p.Thr2Met) variant details
- p.Thr2Met
- NCI-TCGA Cosmic COSV6683
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.776
- REVEL 0.77
- CADD 26.20
- PolyPhen-2 0.78
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available