Y90S (p.Tyr90Ser) variant of ITK (Tyrosine-protein kinase ITK/TSK)
Y90S (p.Tyr90Ser) in ITK (Tyrosine-protein kinase ITK/TSK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data, published literature, and structural context.
Y90S (p.Tyr90Ser) variant details
- p.Tyr90Ser
- gnomAD 5-157211312-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.854
- REVEL 0.97
- ESM-1b 1.00
- AlphaMissense 0.93
- CADD 26.20
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available