Q10P (p.Gln10Pro) variant of ITK (Tyrosine-protein kinase ITK/TSK)
Q10P (p.Gln10Pro) in ITK (Tyrosine-protein kinase ITK/TSK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, published literature, and structural context.
Q10P (p.Gln10Pro) variant details
- p.Gln10Pro
- gnomAD 5-157181006-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.403
- REVEL 0.40
- ESM-1b 0.00
- AlphaMissense 0.11
- CADD 23.70
- PolyPhen-2 0.38
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available