K77I (p.Lys77Ile) variant of ITK (Tyrosine-protein kinase ITK/TSK)
K77I (p.Lys77Ile) in ITK (Tyrosine-protein kinase ITK/TSK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data, published literature, and structural context.
K77I (p.Lys77Ile) variant details
- p.Lys77Ile
- gnomAD 5-157208980-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.742
- REVEL 0.76
- ESM-1b 1.00
- AlphaMissense 0.84
- CADD 25.20
- PolyPhen-2 1.00
- SIFT 0.06
- Population evidence available
- Structural context available
- Literature evidence available