K67E (p.Lys67Glu) variant of ITK (Tyrosine-protein kinase ITK/TSK)
K67E (p.Lys67Glu) in ITK (Tyrosine-protein kinase ITK/TSK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
K67E (p.Lys67Glu) variant details
- p.Lys67Glu
- gnomAD 5-157208949-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.304
- REVEL 0.16
- ESM-1b 0.00
- AlphaMissense 0.14
- CADD 19.60
- PolyPhen-2 0.06
- SIFT 0.87
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available