F41L (p.Phe41Leu) variant of ITK (Tyrosine-protein kinase ITK/TSK)
F41L (p.Phe41Leu) in ITK (Tyrosine-protein kinase ITK/TSK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, published literature, and structural context.
F41L (p.Phe41Leu) variant details
- p.Phe41Leu
- gnomAD 5-157181100-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.493
- REVEL 0.59
- ESM-1b 1.00
- AlphaMissense 0.96
- CADD 21.70
- PolyPhen-2 0.06
- SIFT 0.01
- Population evidence available
- Structural context available
- Literature evidence available