R8G (p.Arg8Gly) variant of ITGB3 (Integrin beta-3)
R8G (p.Arg8Gly) in ITGB3 (Integrin beta-3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
R8G (p.Arg8Gly) variant details
- p.Arg8Gly
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.343
- MetaLR 0.05
- MetaSVM -1.04
- CADD 13.10
- PolyPhen-2 0.00
- SIFT 0.44
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 1.1e-06)
- Structural context available