T77N (p.Thr77Asn) variant of IRF8 (Interferon regulatory factor 8)
T77N (p.Thr77Asn) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data, published literature, and structural context.
T77N (p.Thr77Asn) variant details
- p.Thr77Asn
- gnomAD 16-85909045-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.818
- REVEL 0.85
- CADD 25.10
- PolyPhen-2 0.93
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available