M22T (p.Met22Thr) variant of IRF8 (Interferon regulatory factor 8)
M22T (p.Met22Thr) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
M22T (p.Met22Thr) variant details
- p.Met22Thr
- ExAC rs751261768
- TOPMed rs751261768
- gnomAD rs751261768
- Missense
- Variant Prioritization Score for Impact Estimate 0.436
- REVEL 0.49
- CADD 21.90
- PolyPhen-2 0.01
- SIFT 0.27
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available