K58R (p.Lys58Arg) variant of IRF8 (Interferon regulatory factor 8)
K58R (p.Lys58Arg) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
K58R (p.Lys58Arg) variant details
- p.Lys58Arg
- TOPMed rs1904882270
- gnomAD rs1904882270
- Missense
- Variant Prioritization Score for Impact Estimate 0.765
- REVEL 0.82
- CADD 33.00
- PolyPhen-2 0.73
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available