K33T (p.Lys33Thr) variant of IRF8 (Interferon regulatory factor 8)
K33T (p.Lys33Thr) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data, published literature, and structural context.
K33T (p.Lys33Thr) variant details
- p.Lys33Thr
- gnomAD 16-85903113-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.763
- REVEL 0.85
- CADD 27.60
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available