I27T (p.Ile27Thr) variant of IRF8 (Interferon regulatory factor 8)
I27T (p.Ile27Thr) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
I27T (p.Ile27Thr) variant details
- p.Ile27Thr
- TOPMed rs914225825
- gnomAD rs914225825
- Missense
- Variant Prioritization Score for Impact Estimate 0.565
- REVEL 0.54
- CADD 23.60
- PolyPhen-2 0.10
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available