E74K (p.Glu74Lys) variant of IRF8 (Interferon regulatory factor 8)
E74K (p.Glu74Lys) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data and structural context.
E74K (p.Glu74Lys) variant details
- p.Glu74Lys
- ExAC rs760464695
- gnomAD rs760464695
- Missense
- Variant Prioritization Score for Impact Estimate 0.807
- REVEL 0.79
- CADD 32.00
- PolyPhen-2 0.86
- SIFT 0.01
- Population evidence available
- Structural context available