E74D (p.Glu74Asp) variant of IRF8 (Interferon regulatory factor 8)
E74D (p.Glu74Asp) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
E74D (p.Glu74Asp) variant details
- p.Glu74Asp
- cosmic curated COSV51896
- ExAC rs79518337
- gnomAD rs79518337
- Missense
- Variant Prioritization Score for Impact Estimate 0.3
- REVEL 0.39
- CADD 14.30
- PolyPhen-2 0.02
- SIFT 0.64
- Most common in the HGDP:DAI population (allele frequency 0.062)
- Structural context available