A73T (p.Ala73Thr) variant of IRF8 (Interferon regulatory factor 8)
A73T (p.Ala73Thr) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
A73T (p.Ala73Thr) variant details
- p.Ala73Thr
- ExAC rs761647639
- TOPMed rs761647639
- gnomAD rs761647639
- Missense
- Variant Prioritization Score for Impact Estimate 0.761
- REVEL 0.74
- CADD 27.60
- PolyPhen-2 0.94
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available