A61T (p.Ala61Thr) variant of IRF8 (Interferon regulatory factor 8)
A61T (p.Ala61Thr) in IRF8 (Interferon regulatory factor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.88 / 1. The record also includes population frequency data, published literature, and structural context.
A61T (p.Ala61Thr) variant details
- p.Ala61Thr
- gnomAD 16-85908996-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.878
- REVEL 0.93
- CADD 29.40
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available