R25C (p.Arg25Cys) variant of IRF4 (Interferon regulatory factor 4)
R25C (p.Arg25Cys) in IRF4 (Interferon regulatory factor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data and structural context.
R25C (p.Arg25Cys) variant details
- p.Arg25Cys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.808
- REVEL 0.97
- CADD 31.00
- PolyPhen-2 1.00
- SIFT 0.00
- MutPred 0.87
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available