L40M (p.Leu40Met) variant of IRF4 (Interferon regulatory factor 4)
L40M (p.Leu40Met) in IRF4 (Interferon regulatory factor 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data and structural context.
L40M (p.Leu40Met) variant details
- p.Leu40Met
- TOPMed rs1761166230
- gnomAD rs1761166230
- Missense
- Variant Prioritization Score for Impact Estimate 0.78
- REVEL 0.86
- CADD 25.10
- PolyPhen-2 1.00
- SIFT 0.00
- MutPred 0.89
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available