L3V (p.Leu3Val) variant of IRF4 (Interferon regulatory factor 4)
L3V (p.Leu3Val) in IRF4 (Interferon regulatory factor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data.
L3V (p.Leu3Val) variant details
- p.Leu3Val
- NCI-TCGA Cosmic COSV1011
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.32
- REVEL 0.38
- CADD 20.00
- PolyPhen-2 0.14
- SIFT 0.00
- MutPred 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.2e-05)