G35S (p.Gly35Ser) variant of IRF4 (Interferon regulatory factor 4)
G35S (p.Gly35Ser) in IRF4 (Interferon regulatory factor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data and structural context.
G35S (p.Gly35Ser) variant details
- p.Gly35Ser
- NCI-TCGA Cosmic COSV1011
- NCI-TCGA Cosmic COSV6670
- TOPMed rs1761165556
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.679
- REVEL 0.70
- CADD 25.40
- PolyPhen-2 0.10
- SIFT 0.04
- MutPred 0.63
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available