G35D (p.Gly35Asp) variant of IRF4 (Interferon regulatory factor 4)
G35D (p.Gly35Asp) in IRF4 (Interferon regulatory factor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data and structural context.
G35D (p.Gly35Asp) variant details
- p.Gly35Asp
- NCI-TCGA Cosmic COSV1011
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.821
- REVEL 0.84
- CADD 31.00
- PolyPhen-2 0.73
- SIFT 0.00
- MutPred 0.65
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available