G35C (p.Gly35Cys) variant of IRF4 (Interferon regulatory factor 4)
G35C (p.Gly35Cys) in IRF4 (Interferon regulatory factor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.81 / 1. The record also includes population frequency data and structural context.
G35C (p.Gly35Cys) variant details
- p.Gly35Cys
- NCI-TCGA Cosmic COSV1011
- NCI-TCGA Cosmic COSV6670
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.81
- REVEL 0.88
- CADD 32.00
- PolyPhen-2 0.97
- SIFT 0.00
- MutPred 0.72
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available