D33N (p.Asp33Asn) variant of IRF4 (Interferon regulatory factor 4)
D33N (p.Asp33Asn) in IRF4 (Interferon regulatory factor 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
D33N (p.Asp33Asn) variant details
- p.Asp33Asn
- NCI-TCGA Cosmic COSV6670
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.686
- REVEL 0.60
- CADD 32.00
- PolyPhen-2 0.78
- SIFT 0.02
- MutPred 0.58
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available