W74R (p.Trp74Arg) variant of IRAK4 (Q9NWZ3)
W74R (p.Trp74Arg) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
W74R (p.Trp74Arg) variant details
- p.Trp74Arg
- gnomAD 12-43771278-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.664
- CADD 28.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available