T77R (p.Thr77Arg) variant of IRAK4 (Q9NWZ3)
T77R (p.Thr77Arg) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
T77R (p.Thr77Arg) variant details
- p.Thr77Arg
- ExAC rs771900851
- gnomAD rs771900851
- Missense
- Variant Prioritization Score for Impact Estimate 0.567
- AlphaMissense 0.15
- MetaLR 0.06
- MetaSVM -1.05
- CADD 22.90
- PolyPhen-2 0.11
- SIFT 0.48
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available