T77K (p.Thr77Lys) variant of IRAK4 (Q9NWZ3)
T77K (p.Thr77Lys) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
T77K (p.Thr77Lys) variant details
- p.Thr77Lys
- ExAC rs771900851
- gnomAD rs771900851
- Missense
- Variant Prioritization Score for Impact Estimate 0.566
- AlphaMissense 0.15
- MetaLR 0.06
- MetaSVM -1.05
- CADD 23.00
- PolyPhen-2 0.05
- SIFT 0.48
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available