T6P (p.Thr6Pro) variant of IRAK4 (Q9NWZ3)
T6P (p.Thr6Pro) in IRAK4 (Q9NWZ3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
T6P (p.Thr6Pro) variant details
- p.Thr6Pro
- ExAC rs780540482
- TOPMed rs780540482
- gnomAD rs780540482
- Missense
- Variant Prioritization Score for Impact Estimate 0.473
- CADD 24.30
- PolyPhen-2 0.92
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available